The goal of this study was to enhance therapeutic effectiveness for a drug with a short half-life and a strong first-pass effect, as well as reduce dose frequency and target drug release. Hence to create and construct diltiazem hydrochloride nanofiber mats for the treatment of hypertension, diltiazem hydrochloride was selected as a model medication. The nanofiber mat was developed utilizing fibres with nanoscale diameters and a higher surface area, resulting in a more successful treatment impact. Scanning electron microscopy has been used to assess the shape and diameter of the mats (SEM). Mats were also studied for their physical properties, total drug content, disintegration time, and in vitro drug release. The drug was really in the mats, which had good tensile strength and was also physically stable. The drug dissolved quickly and effort to remove. Mat disintegration time and drug release could be adjusted by varying concentrations of polymers. The bitter taste of diltiazem was masked by using aspartame and menthol. According to the findings, created nanofiber mats might perform better for improving drug loading efficacy, bypassing the first-pass effect, minimising the dose, and improving patient compliance through an effective alternative mode of administration.