Error message

Deprecated function: The each() function is deprecated. This message will be suppressed on further calls in theme_biblio_custom() (line 367 of /home/ajbls/public_html/sites/all/modules/biblio/includes/biblio_theme.inc).

Designing a Nanofiber Mats as a Targeted Approach of Diltiazem Hydrochloride for Management of Hypertensive Conditions

Asian Journal of Biological and Life Sciences,2022,11,2,570-577.
Published:September 2022
Type:Research Article
Authors:
Author(s) affiliations:

Rajappa Margret Chandira1,*, Palanisamy Pethappachetty2, Tamilarasan Murugan2, Dominic Antony samy3

1Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem, Tamil Nadu, INDIA.

2Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem, Tamil Nadu, INDIA.

3Sona College of Technology, Salem, Tamil Nadu, INDIA.

Abstract:

The goal of this study was to enhance therapeutic effectiveness for a drug with a short half-life and a strong first-pass effect, as well as reduce dose frequency and target drug release. Hence to create and construct diltiazem hydrochloride nanofiber mats for the treatment of hypertension, diltiazem hydrochloride was selected as a model medication. The nanofiber mat was developed utilizing fibres with nanoscale diameters and a higher surface area, resulting in a more successful treatment impact. Scanning electron microscopy has been used to assess the shape and diameter of the mats (SEM). Mats were also studied for their physical properties, total drug content, disintegration time, and in vitro drug release. The drug was really in the mats, which had good tensile strength and was also physically stable. The drug dissolved quickly and effort to remove. Mat disintegration time and drug release could be adjusted by varying concentrations of polymers. The bitter taste of diltiazem was masked by using aspartame and menthol. According to the findings, created nanofiber mats might perform better for improving drug loading efficacy, bypassing the first-pass effect, minimising the dose, and improving patient compliance through an effective alternative mode of administration.