Structural, Optical, Antibacterial and Anticancer Properties Silver Barium Modified Titanium Dioxide Nanoparticles Prepared via a Green Process Using Withania somnifera Hairy Roots

Raja Palusamy; Thiagu Ganesan; Appakan Shajahan; Thilip Chandrasekaran; Alagar yadav Sangilimuthu; Liyahathalikhan Umaralikhan

Asian Journal of Biological and Life Sciences,2023,12,2,294-300.

DOI:10.5530/ajbls.2023.12.40

Published:September 2023

Type:Research Article

Authors:

Author(s) affiliations:

Raja Palusamy¹, Thiagu Ganesan¹, Appakan Shajahan^1,*, Thilip Chandrasekaran², Alagar Yadav Sangilimuthu³, Liyahathalikhan Umaralikhan⁴

¹Department of Botany, Plant Molecular Biology Laboratory, Jamal Mohamed College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, INDIA.

²Department of Botany, Government Arts and Science College, Sendamangalam, Namakkal, Tamil Nadu, INDIA.

³Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, INDIA.

⁴Department of Physics, Jamal Mohamed College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, INDIA.

Abstract:

Aims: The current study sought to assess the antibacterial and anticancer properties of AgBamodified TiO₂ nanoparticles produced by a green method using a hairy root extract from Withania somnifera. Materials and Methods: The synthesized samples were examined through X-ray Diffraction (XRD) investigations, SEM and Energy-Dispersive X-ray analysis (EDX), Dynamic Light Scattering (DLS), Fourier Transform Infrared (FTIR) Spectroscopy, Ultraviolet (UV) Spectroscopy, and Photoluminescence (PL) spectra. Results: SEM validated the produced nanoparticle’s sphericallike shapes with EDX analysis, which confirmed the crystallite size of 70 nm as determined by DLS. In addition, oxygen vacancies in synthesized nanoparticles were found between 501 and 521 nm in the PL spectra. Conclusion: The primary focus of this study is on the environmentally friendly plant-based synthesis of biomedically important AgBa-modified TiO₂ using aqueous Withania somnifera hairy root, and it has the potential antibacterial against S. aureus, S. pneumoniae, B. subtilis, K. pneumoniae, E. coli, P. vulgaris and anticancer activity against blood cancer cell lines (MOLT-4).