Microbial volatile organic compounds (MVOCs) are organic compounds having low molecular mass (less than 300 Da) and high vapor pressure due to low boiling point. Microorganisms produce a plethora of volatile compounds that can play a very crucial role in intra- and inter-kingdom interactions. Many volatile organic compounds (VOCs) secreted by microbes associated with soil and plants have been described to be involved in microbial communications. A considerable body of opinion indicates that MVOCs have potential to be utilized as a beneficial and good sustainable approach for diverse areas including agriculture, industrial and health sector. They can induce plant defense systems and inhibit the development of diverse plant pathogens.