Therapeutic Potential of Citrus Flavonoid Naringin in Management of Osteoporosis: Current Status and Future Perspectives

Mukesh Yadav; Nirmala Sehrawat; Sunil Kumar; Anil Kumar Sharma; Nipunjot Kaur; Amandeep Singh; Rachna Nara; Sachin Kumar

Asian Journal of Biological and Life Sciences,2021,10,3,527-532.

DOI:10.5530/ajbls.2021.10.70

Published:January-2022

Type: Review Article

Authors:

Author(s) affiliations:

Mukesh Yadav^1,*, Nirmala Sehrawat¹, Sunil Kumar¹, Anil Kumar Sharma¹, Nipunjot Kaur², Amandeep Singh^1,2, Rachna Nara¹, Sachin Kumar³

¹Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, INDIA.

²G.S.S.D.G.S. Khalsa College, Patiala, Punjab, INDIA.

³Department of Bioinformatics, Janta Vedic College, Baraut-Baghpat, Uttar Pradesh, INDIA.

Abstract:

Naringin is a plant based natural compound abundantly present in citrus fruits. Naringin has been reported for its vast range of therapeutic properties and it has been recognized as molecule of interest in treatment of various diseases. Naringin has been also investigated for its role in promoting bone development and maintenance. It has been found to promote bone formation and inhibit the bone resorption. It seems to be a potent candidate in treatment of osteoporosis. Osteoporosis is characterized by low bone mass and destruction of bone microstructure. Osteoporosis increases the risk of bone fracture. Naringin has been found effective in treatment of osteoporosis and improvement of bone health including bone mineral density and mechanical strength. In current review, the potential of naringin in treatment of osteoporosis has been reviewed. This article will provide important and concise information on therapeutic potential of naringin against osteoporosis.

Keywords:Alternate medicine, Bone formation, Bone health, Bone resorption, Naringin, Osteoporosis