Background: The development of advanced wound care solutions is critical due to the significant global impact of chronic and acute wounds. This study focuses on fabrication of a biodegradable and biocompatible nanofibre scaffold for enhanced wound healing, combining antimicrobial and anti-inflammatory properties. Objectives: The present research work was carried out to fabricate and evaluate nanofibres loaded with ozenoxacin (anti-microbial agent) and curcumin (antiinflammatory agent) for their potential in advanced wound management. Materials and Methods: The current study was carried out during December 2023 to July 2024. Nanofibres were developed using electrospinning with a Polyvinyl Alcohol (PVA) and gelatin blend, incorporating with ozenoxacin and curcumin as therapeutic agents. Results: The viscosity of the polymer solution prior to electrospinning was found to be at 39.48 Pa.s, ensuring optimal fibre formation. Scanning Electron Microscopy confirmed uniform fibres with diameters between 50-114 nm. Fourier-Transform Infrared Spectroscopy (FT-IR) and X-ray Diffraction (XRD) analyses verified that there is no chemical interaction and further crystalline nature of the incorporated agents respectively. In vitro release studies demonstrated a sustained release profile of both ozenoxacin and curcumin over 24 hr, indicating prolonged therapeutic potential. Folding endurance tests revealed that the nanofibres could withstand up to 93 folds without breaking, indicating good mechanical robustness. The study found that ozenoxacin-loaded nanofibers have excellent hydration capacity and drug entrapment efficiency, with encapsulation rates of 76.92%. Conclusion: This dual-functional scaffold addresses infection control and inflammation reduction, offering a comprehensive approach to wound management. The synergistic effect of ozenoxacin and curcumin accelerates wound healing; making it a promising candidate for advanced wound care applications.
View:
- PDF (1.36 MB)
