Adult-Onset Still’s Disease [AOSD] is a rare inflammatory condition that causes fevers spikes, arthritis and rashes. It can be difficult to diagnose because its symptoms are similar to other diseases. In the case of a 46 year old male with a history of high fever for one week, followed by five days of sore throat and dry cough and two days of multiple joint pains. The patient had no known comorbidities but had a previous hospitalization for brucellosis in 2020 and an amoxicillin allergy. Despite initial treatment with Moxifloxacin and Doxycycline therapy, followed by prophylactic administration of Meropenem, the fever persisted. Laboratory testing revealed leukocytosis, increased ESR and elevated ferritin levels. CT imaging showed hepatosplenomegaly and sub-pleural fibrotic spots. The AOSD diagnosis was confirmed based on Yamaguchi Criteria including salmon-coloured maculopapular rashes, elevated inflammatory markers, medical history, elevated ferritin levels and imaging findings. Treatment with anti-inflammatory medications and corticosteroids resulted in significant clinical improvement. The patient was discharged on the seventh day with prescriptions for pantoprazole, prednisolone and naproxen and was advised to follow up after one week. This case highlights the importance of early diagnosis and aggressive treatment for managing AOSD, highlighting the effectiveness of steroids for symptom relief.
