Bio-functionalized Gold Nanoparticles: A Potent Probe for Profound Antibacterial Efficiency through Drug Delivery System

Manoj Singh; Subramanian Manikandan; Mukesh Yadav; Sunil Kumar; Nirmala Sehrawat; Vikas Meashi; Diksha; Pranjal Sharma; Anil Kumar Sharma

Asian Journal of Biological and Life Sciences ,2020,9,2,139-144.

DOI:10.5530/ajbls.2020.9.21

Published:September 2020

Type:Research Article

Authors:

Author(s) affiliations:

Manoj Singh^1,2*, Subramanian Manikandan³, Mukesh Yadav¹, Sunil Kumar¹, Nirmala Sehrawat¹, Vikas Meashi¹, Diksha¹, Pranjal Sharma¹, Anil Kumar Sharma¹

¹Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, INDIA.

²Laboratory of Biomedical Nanomaterials, National University of Science and Technology "MISiS", Moscow, Leninsky Prospect, RUSSIA.

³Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran, KSA.

Abstract:

In the present manuscript, we reported extracellular biosynthesis of gold nanoparticles through extract of leaves from Dictyota dichotoma. Biosynthesized nanoparticles were characterized using UV– Vis spectroscopy, HRTEM, EDX and FTIR spectroscopy. The polyshaped gold nanoparticles of size 8±21 nm were synthesized. The antibacterial activities were observed by the agar well diffusion method for the action of Streptomycin and Gentamycin and their formulation with biocapped gold nanoparticles. The profound efficacies were supported by the increase in fold area of inhibition against the tested bacteria. The appropriate cause of this divergence has also been discussed due to suitable binding of biogenic gold nanoparticles with drugs and supports these findings to overcome the conflict of previously reported data.

Keywords:Antibacterial efficacy, Biomimetic, Dictyota dichotoma, Drug delivery systems