Background: The in vitro study was conducted to determine the antibacterial efficiency of commercially accessible dentifrices against strains of S. mutans. Materials and Methods: The study assessed the 5 commercially accessible toothpastes and designated as M, C, TA, X and PE. The strain of S. mutans MTCC 890 was utilized and the agar well diffusion technique was employed to assess antibacterial effectiveness. The diameter of the Inhibition Zone (ZOI) was determined after 24 and 48 hr of incubation. The ANOVA and Tukey’s post hoc tests were applied to determine the mean variations among the dentifrices using SPSS software. Results: Group TA exhibits the highest average diameter against S. mutans, measuring 28.37±1.72 (24 hr) and 29.36±1.27 (48 hr). Group M exhibited the minimal zone of inhibition, measuring 23.25±0.43 at 24 hr and 23.14±0.74 at 48 hr. The comparison of various dentifrices indicated a significant difference in ZOI. The post hoc test indicated statistically significant differences in the ZOI at 24 hr relative to other groups, except for Group C vs Group PE (p=0.13), Group TA vs Group X (p=0.12) and Group X vs Group PE (p=0.19). The mean ZOI at 48 hr also showed significant variations in mean ZOI values, except for Group C vs. Group X (p=0.056), Group C vs. Group PE (p=0.52) and Group PE vs. Group X (p=0.12). Conclusion: The evaluated toothpaste was efficacious against S. mutans at 24 and 48 hr. Group TA containing 1450 ppm of sodium fluoride was superior in inhibiting S. mutans and Group M had minimal efficacy.
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