Aim: Chemoprevention, an emerging promising technique for experimental oncology, focuses on the use of natural creates to inhibit or prevent the progression of malignancy. In this study, the chemopreventive ability of TD (Trianthema decandra) root extract was studied in regard to DMBAinduced HBPs. Materials and Methods: Painted the left Buccal pouches mixture of 0.5% DMBA in liquid paraffin weekly thrice for 14 weeks, and the result was the development of buccal cancer. In hamsters given in two ways, DMBA alone or DMBA+TD root extract treatment, tumour development measurement, detoxification agents, Lipid Peroxidation (LPO), antioxidant status, renal function markers and histological alterations were evaluated. Results: Hamsters provided the treatment demonstrated 100% tumour happenings with a DMBA alone causes an imbalance in the Enzymes to break up carcinogens renal function identifiers and cellular redox state. When administered orally to hamsters undergoing DMBA medication, TD root extract, entirely prevented the formation of tumors and Cellular redox state and enzymes that break down carcinogens. Conclusion: TD root extract will be a conventional medicine for rejuvenating and nephrogenic remedies, and shows promising chemopreventive efficacy in DMBA-induced HBPs Cancer.