The goal of this study was to create a Nanosponges formulation of Domperidone for oral capsule solubility and bioavailability enhancement of the drug. They have an established spherical colloidal nature, and their inclusion and non-inclusion behaviours show that they have a very high BCS class II drug solubilization capability. The physicochemical characterization for a pure drug such as organoleptic properties, spectral analysis UV spectroscopic studies, ATR-FTIR and DSC were investigated and confirmed. Preformulation studies such as solubility studies, angle of repose, tapped density, cars index, bulk density and Hausner ratio are performed for blend powder showing micromeritic characteristics are within the pharmacopeial specifications. The emulsion solvent diffusion method is used to formulate drug-loaded Nanosponges, and the capsule filling process is used to make the capsules. The drug-loaded nanosponges prepared were evaluated for surface morphology analysis (SEM), percent yield and entrapment efficiency show the nanosponges have a spherical form and a smooth surface morphology at 200nm. Then the prepared capsules were subjected to evaluation tests including dissolution studies that lasted up to 12 hr The stability studies were conducted for the optimized formulation (period of three-month) stability assessment at accelerated and room temperature. Based on the results of various studies, it is concluded that the Domperidone loaded nanosponge capsules formulation provide an effective modified formulation for the oral route of administration.
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