Influence of Fluoride Exposure on Hypothalamic Pitutary Gonadal Axis Hormones and Semen Quality

Asian Journal of Biological and Life Sciences ,2013,2,3,201-206.
Published:December 2013
Type:Research Article
Author(s) affiliations:

Dushyant Singh Chauhan1,2, Vivek Pratap Singh1,2, Sudhanshu Mishra , Sandeep Tripathi1,2, Mukesh Tiwari1,3, Anurag Tomar1,4

1National Referral Centre for Fluoride Poisoning in India, Nims University, Jaipur, INDIA.

2Department of Advanced Sciences & Biotechnology, Nims Institute of Engineering & Technology; Nims University, Jaipur -303121, INDIA.

3Departments of Orthopedics, Nims Medical College & Hospital, Nims University, Jaipur, INDIA.

4Departments of Pediatrics, Nims Medical College & Hospital, Nims University, Jaipur, INDIA.


The main objective of the present study was to explore the influence of fluoride exposure on reproductive hormones in different stages of fluorosis. Since, fluoride has been reported to be a causative factor for reduced semen quality. However, limited scientific literature is available on this aspect of effect of fluoride on clinical samples. In the present study, we recruited 75 fluorotic patients (age 25-35) and categorize in three groups namely mild, moderate and severe. Each group was included 25 patients. The controls were selected from the Jaipur district, Rajasthan India, where fluoride content in ground water was <1.5ppm. Fasting blood samples was collected for the estimations of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TT) and prolactin. Semen samples were also collected for the investigation of sperm physiology. The results of the present study showed significantly (p<0.05) reduced semen volume, liquefaction time, viability, motility and semen viscosity in all groups of fluorotic patients as compared with the controls. On the other hand, we observed markedly (p<0.05) increased serum FSH and prolactin and decreased LH and testosterone levels as per the severity of disease. On the basis of results it may conclude that excessive fluoride exposure accelerate the severity of disease along with the altered hormonal profiles and reduced semen quality. A positive correlation was observed between fluoride, hypothalamic gonadal axis and semen quality.