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Circadian Proteins and Reproduction: An Update

Asian Journal of Biological and Life Science,2013,2,2,83-88.
Published:August 2013
Type:Review Article
Authors:
Author(s) affiliations:

Kumari Nishi1, Swarndeep Singh Hundal1,*, Vinoth Prasanna Gunasekaran2

1Department of Zoology, Punjab Agricultural University, Ludhiana, Punjab-141004, INDIA.

2Department of Biomedical Science, School of Basic Medical Sciences, Bharathidasan University, Tiruchirappalli, Tamilnadu - 620 024, INDIA

Abstract:

Endogenous circadian rhythms play an important role in effective functioning of complex organisms to enhance their survival. The master clock or suprachiasmatic nucleus in the ventral hypothalamus helps synchronize all independent peripheral clocks for temporal regulation of all physiological activities. The important clock proteins are Circadian Locomotor Output Cycle Kaput (CLOCK), Brain-Muscle-Arnt-Like protein 1 (BMAL1), Cryptochrome (CRY) and Period (PER). These proteins have a role in reproduction and functioning of gonads. The expression of these proteins is controlled by a histone deacetylase Sirtuin1 (SIRT1). The presence, role and functioning of these compounds in the reproductive tissues is discussed.

Keywords:Nil