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Antimutagenic Activity of Probiotic Bifidobacterium and Lactobacillus spp. by Ames Test

Asian Journal of Biological and Life Science,2013,2,2,142-145.
Published:August 2013
Type:Research Article
Author(s) affiliations:

Reza kazemi Darsanaki1,*, Morteza Azizollahi Aliabadi2, Mohammad Mohammad Doost Chakoosari2, Abolfazl Amini3, Fatemeh (Elham) Alikhani2

1Young Researchers Club, Lahijan Branch, Islamic Azad University, Lahijan, IRAN

2Department of Microbiology, Faculty of Science, Lahijan Branch, Islamic Azad University, Lahijan, IRAN

3Laboratory Science Research center, Laboratory Sciences Department School of Paramedical, Golestan University of Medical Sciences, Gorgan, IRAN


Probiotics are live microbial food supplements that are considered to be beneficial for humans and animals. Many researchers have showed that probiotic bacteria can be effective to decrease cancer risk. In this study, Antimutagenic activities of four probiotic Bifidobacterium and Lactobacillus spp. against three potent mutagen acrylic amide, sodium azide and 2-nitrofluorene were examined by Ames test using Salmonella typhimurium TA100. Results showed Bifidobacterium and Lactobacillus spp. can inhibit mutagen agents unit 40%, That is very good antimutagenic activity. Bifidobacterium bifidum PTCC 1644 displayed the highest antimutagenic activity than other bacteria (inhibition 52.22% acrylic amide, 50.80% sodium azide and 48.66%, 2-nitrofluorene). Antimutagenic activity was increased significantly when there were liver microsome extract (S ).