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Evaluation of General Behavioral Activities of Aloe vera (L) burm.f

Asian Journal of Biological and Life Sciences ,2012,1,1,61-65.
Published:May 2012
Type:Short Communication
Authors:
Author(s) affiliations:

Nuzhat Sultana1,*, Rahila Najam2

1Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, PAKISTAN.

2Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, PAKISTAN.

Abstract:

Anxiety is the natural human response to motivate to solve the problems. Under pressure, person is facing a stressful situation in anxiety. Although it is a normal human emotion but symptoms escalate into anxiety attack, it may be anxiety disorder. Aloe vera was evaluated for general behavioral activities in mice, different behavioral activities for anxiety. Aloe vera was administered orally in both sexes of mice found to cause significant depression in general as well as behavioral profiles. The results revealed that Aloe vera showed significant reduction (<0.01) in awareness, alertness, mood, locomotor, touch response, motor coordination, and passivity and spontaneous activity with highly significant decrease (<0.001) in pain response with significant increase (<0.01) in sedation. The result suggests that Aloe vera can possesses anxiolytics and CNS depressive potential with sedation at long-term use and required further investigation.

Keywords:Nil