Azadirachta indica (A) Juss which is commonly called Neem was introduced to Nigeria from Ghana, and was first grown from the seeds in Maiduguri, in the then Bornu province (Now Borno State), Nigeria in 1928. Aside its medicinal importance, neem products have great pesticidal and most especially insecticidal potential. Various neem formulations such as oil, seed kernel powder and, leaf and seed kernel extracts have been experimented for the control of different insect pests with appreciable success thereby bringing to the fore the potential of neem in insect pest management. However, for these research findings to be propagated and accepted by our low-resource/grass-root farmers, who happens to be the backbone of Nigerian Agriculture, the researches need to be holistic; hence the following aspects which so far have not received serious attention are recommended for further investigation in Nigeria. These aspects include; on farm trials, cost benefit analysis of neem based pesticides, evaluation of the potential of neem products to act as synergists/to be synergized particularly by other botanicals, determination of neem trees with better insecticidal properties; environmental impact, phytotoxicity, pest resurgence and pest resistance assessments of neem based pesticides.