Freshwater bivalves, Lamellidens corrianus were exposed to acute dose of tetracycline one of the broad spectrum antibiotics, 369.10PPM, and Parreysia cylindrica 166.54PPM up to 96 h. In Lamellidens corrianus the concentration used for chronic treatment of tetracycline was 73.82 PPM, while P. cylindrica 33.30 PPM up to 21 days. The total lipid content was estimated after 24 and 96 h of acute treatment and 7, 14 and 21 days of chronic treatment in the mantle, gills, foot, ovary, testis, whole body and digestive gland of the bivalves. After acute and chronic exposure of tetracycline, L. corrianus and P. cylindrica showed increase in total lipid contents. There was overall increase in lipid contents in different tissues of both the species of bivalves. Ovary showed maximum response against the tetracycline treatment. Maximum increase in lipid contents was found in ovary after chronic treatment of tetracycline. The increase in lipid contents may be due to the lipogenesis occurring in the ovary for production of gametes
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